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|TITLE||Hyperkeratinization, Corneocyte Cohesion, and Alpha Hydroxy Acids|
|AUTHOR||Eugene J. Van Scott, MD & Ruey J. Yu, PhD|
|PUBLICATION||Journal of American Academy of Dermatology|
Hyperkeratinization is a primary or fundamental event in a majority of today’s skin disorders. Hyperkeratinization is usually the result of decreased desquamation due to increased corneocyte cohesion. Strength of corneocyte cohesionP is determined by strength of intercellular bonding. Intercellular bonding is weakened by water and diminished by retinoids and alpha hydroxyl acids (AHAs). Conversely, bonding is strengthened or enhanced by dehydration, vitamin A deficiency, and some alpha acetoxy acids (AAAs). Agents that control or modify keratinzation can be useful in treatment of many skin disorders.
Corneocyte cohesion – Dead skin cells stuck to the surface of the skin
Removing of dead skin cells from skin surface
Separation of dead skin cells from skin surface after using 5% glycolic acid in hydrophilic ointment four times daily for 24 hours
Promotes regularity of skin condition in as soon as 3 weeks
After application of 4 times daily of 5% glycolic aicd in hydrophilic ointment for 1 week and once daily for the next 2 weeks.